論文 | pharmaceutics

Yoshizawa, Izumi; Mizuochi, Toshiaki; Ogata, Akio; Murakami, Masahiro; Yagaita, Hideo; Takahashi, Yoshimasa; Mizuochi, Tsuguo; Takemori, Toshitada; Tsunetsugu-Yokota, Yasuko. Studies on the Generation and Maintenance of Mucosal Cytotoxic T Lymphocytes against Human Immunodeficiency Virus Type 1 Gag in Mice. AIDS Research and Human Retroviruses, 19(6), 469-479 (2003)
OYANAGUI Y, TANIGUCHI M, IWATA M, MURAKAMI M, Inhibition of immunoglobulin G-catalyzed hydrogen peroxide generation by dexamethasone and piroxicam. Life Sci, Vol.73, No.10, 1333-1346 (2003)
OYANAGUI Y, TANIGUCHI M, IWATA M, MURAKAMI M, Inhibition of immunoglobulin G-catalyzed hydrogen peroxide generation by dexamethasone and piroxicam. Life Sci, Vol.73, No.10, 1333-1346 (2003)
KOGA K, KAWASHIMA S, SHIBATA N, TAKADA K, MURAKAMI M, Preparation and Rectal Absorption of Highly Concentrated Glycyrrhizin Solution. Biol Pharm Bull, Vol.26, No.9, 1299-1305 (2003)
EIAMTRAKARN S, ITOH Y, KISHIMOTO J, YOSHIKAWA Y, SHIBATA N, MURAKAMI M, TAKADA K, Gastrointestinal mucoadhesive patch system (GI-MAPS) for oral administration of G-CSF, a model protein. , Biomaterials, Vol.23, No.1, 145-152 (2002)
SHIBATA N, OHNO T, SHIMOKAWA T, HU Z, YOSHIKAWA Y, MURAKAMI M, TAKADA K, KOGA K, Application of pressure-controlled colon delivery capsule to oral administration of glycyrrhizin in dogs. J Pharm Pharmacol, Vol.53, No.4, 441-447 (2001)
UCHIYAMA T, KOTANI A, TATSUMI H, KISHIDA T, OKAMOTO A, OKADA N, MURAKAMI M, FUJITA T, YAMAMOTO A , Development of Novel Lipophilic Derivatives of DADLE (Leucine Enkephalin Analogue): Intestinal Permeability Characteristics of DADLE Derivatives in Rats. Pharm Res, Vol.17, No.12, 1461-1467 (2000)
SHIBATA N, SHIMOKAWA T, JIANG Z-Q, JEONG Y-I, OHNO T, KIMURA G, YOSHIKAWA Y, TAKADA K, KOGA K, Characteristics of Intestinal Absorption and Disposition of Glycyrrhizin in Mice. Biopharm Drug Dispos, Vol.21, No.3, 95-101 (2000)
KOGA K, KAWASHIMA S, OHMACHI K, MURAKAMI M, TAKADA O, Determination of 18α-glycyrrhizin and 18β-glycyrrhizin in dog plasma by high-performance liquid. chromatography. J Chromatogr B, Vol.738, No.1, 165-168 (2000)
KOGA K, OHYASHIKI T, KAWASHIMA S, MURAKAMI M, Modification of ceftibuten transport by the addition of non-ionic surfactants. Eur J Pharm Biopharm, Vol.49, No.1, 17-25 (2000)
YOSHIKAWA Y, HU Z, KIMURA G, MURAKAMI M, TAKADA K, YOSHIKAWA H, A Dissolution Test for a Pressure-controlled Colon Delivery Capsule: Rotating Beads Method. J Pharm Pharmacol, Vol.51, No.9, 979-989 (1999)
KOGA K, KAWASHIMA S, MURAKAMI M, Effects of Fatty Acid Glycerol Esters on Intestinal Absorptive and Secretory Transport of Ceftibuten. Biol Pharm Bull, Vol.22, No.4, 402-406 (1999)
KOGA K, KAWASHIMA S, MURAKAMI M, Modification of Ceftibuten Transport by Changes in Lipid Fluidity Caused by Fatty Acid Glycerol Esters. Biol Pharm Bull, Vol.22, No.1, 103-106 (1999)
SASAKI I, TOZAKI H, MATSUMOTO K, ITO Y, FUJITA T, MURAKAMI M, MURANISHI S, YAMAMOTO A, Development of an Oral Formulation of Azetirelin, a New Thyrotropin-Releasing Hormone (TRH) Analogue, Using n-Lauryl-β-D-maltopyranoside as an Absorption Enhacer. Biol Pharm Bull, Vol.22, No.6, 611-615 (1999)
Tozaki H, Odoriba T, Iseki T, Taniguchi T, Fujita T, Murakami M, Muranishi S, Yamamoto A., Use of protease inhibitors to improve calcitonin absorption from the small and large intestine in rats. J Pharm Pharmacol. 50(8), 913-920 (1998)
Tomomi Uchiyama, Atsushi Kotani, Takeshi Kishida, Hiroyuki Tatsumi, Aya Okamoto, Takuya Fujita, Masahiro Murakami, Shozo Muranishi, Akira Yamamoto, Effects of protease inhibitors on the stability and permeability of [D-Ala2, D-Leu5]enkephalin in the rat intestine: Comparison with leucine enkephalin. J. Pharm. Sci., 87(4): 448-452 (1998).
Ying-shu Quan, Koji Hattori, Ewa Lundborg, Takuya Fujita, Masahiro Murakami, Shozo Muranishi, Akira Yamamoto, Effectiveness and toxicity screening of various absortion enhancers using Caco-2 cell monolayers, Biol. Phar. Bull., 21(6):615-620 (1998).
Murakami, Masahiro; Uchiyama, Tomomi; Tatsumi, Hiroyuki; Majikawa, Yoshikatsu; Obata, Hidenori; Imaoka, Nao; Sasaki, Kayoko; Tomoda, Yutaka; Muranishi, Shozo. Methodology for evaluating inflammation induction potential of enteral absorption enhancers. Epithelial permeability enhancement via histamine receptors. Drug Delivery System, 13(2), 107-113. (1998)
Kenjiro Koga, Masahiro Murakami, Susumu Kawashima, Effects of fatty acid sucrose esters on ceftibuten transport by rat intestinal brush-border membrane vesicles. Biol. Pharm. Bull., 21(7): 747751 (1998).
Shozo Muranishi, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Potential for lymphatic targeting of peptides. J. Control. Release, 46:157-164 (1997).
Isao Sasaki, Takashi Tamura, Tomoko Shibakawa, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi, Metabolism of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, by intestinal microorganisms. Pharm. Res., 14: 1004-1007 (1997).
Kenjiro Koga, Masahiro Murakami, Susumu Kawashima, Contribution of fluidity to the uptake of disopyramide by rat intestinal brush-border membrane vesicles. Biol. Pharm. Bull. 20:674-679 (1997).
Koichiro Tanaka, Takuya Fujita, Toshihiko Yamamoto, Masahiro Murakami, Akira Yamamoto, and Shozo Muramishi, Enhancement of intestinal transport of thyrotropin-releasing hormone via a carrier-mediated system by chemical modification with lauric acid, Biochim. Biophys. Acta, 1283:119-126(1996)
Shozo Muranishi, Takuya Fujita, Masahiro Murakami, and Akira Yamamoto, Lymphatic transfer of macromolecules after intrapulmonary administration in the presence or absence of various absorption enhancers in rats. The Pharmazie, 51:331-336 (1996).
Kazunari Setoh, Masahiro Murakami, Naoko Araki, Fujita Takuya, Akira Yamamoto, and Shozo Muranishi, Improvement of transdermal delivery of tetragastrin by lipophilic modification with fatty acids. J. Pharm. Pharmacol., 47:808-811 (1995).
Isao Sasaki, Kouichiro Tanaka, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi, Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue II: Biol. Pharm. Bull., 18:891-894 (1995).
Takashi Tamura, Takuya Fujita, Yukiko Itoh, Satomi Sugimoto, Hidenori Yamada, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi, Synergistic anti-tumor effects of mitomycin C and bile salts against L12to cells. Biol. Pharm. Bull., 18:1109-1113 (1995).
Hiroyuki Asada, Takayuki Douen, Yoshiko Mizokoshi, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi, Stability of acyl derivatives of insulin in the small intestine: relative importance of insulin association characteristics in aqueous solution. Pharm. Res., 11:1115-1120 (1994).
Hiroyuki Asada, Takayuki Douen, Yoshiko Mizokoshi, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi, Stability of acyl derivatives of insulin in the small intestine: relative importance of insulin association characteristics in aqueous solution. Pharm. Res., 11:1115-1120 (1994).
Hiroyuki Asada, Takayuki Douen, Yoshiko Mizokoshi, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi, Stability of acyl derivatives of insulin in the small intestine: relative importance of insulin association characteristics in aqueous solution. Pharm. Res., 11:1115-1120 (1994).
Toshio Taniguchi, Kaori Rikyu, Tomoko Tsuji, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi, Regional differences in the efffects of various protease inhibitors on the intestinal absorption and stability of insulin and calcitonin in rats. Pharm. Res., 11:1496-1500 (1994).
Isao Sasaki, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Eiji Nakamura, H. Imasaki, Shozo Muranishi, Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue I: possible factors for the low bioavailability in rats. Biol. Pharm. Bull., 16:1256-1261 (1994).
Taishi Okagawa, Takuya Fujita, Masahiro Murakami, Akira Yamamoto and Shozo Muranishi, Susceptibility of ebilatide to proteolysis in rat intestinal fluid and homogenates and its protection by various protease inhibitors. Life Science, 55:677-683 (1994).
Etsuo Yodoya, Kazuyo Uemura, Takehiro Tennma, Takuya Fujita, Masahiro Murakami, Akira Yamamoto and Shozo Muranishi, Enhanced permeability of tetragastrin across the intesitinal membrane and its reduced degradation by acylation with various fatty acids in rats. J. Pharmacol. Exp. Ther., 271(3): 1509-1513 (1994)
Hiroyuki Asada, Takayuki Douen, Yoshiko Mizokoshi, Takuya Fujita, Masahiro Murakami, Akira Yamamoto and Shozo Muranishi, Stability of acyl derivertives of insulin in the small intestine: relative importance of insulin association charactoristics in aqueous solution. Pharm. Res., 11(8): 1115-1120 (1994).
Akira Yamamoto, Toshio Taniguchi, Kaori Rikyuu, Tomoko Tusji, Takuya Fujita, Masahiro Murakami and Shozo Muranishi, Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. Pharm. Res., 10 (11): 1496-1500 (1994).
Takehiro Tennma, Etsuo Yodoya, Shigeru Tashima, Takuya Fujita, Masahiro Murakami, Akira Yamamoto and Shozo Muranishi, Development of new lipophilic derivertives of tetragastrin: physicochemical characteristics and intestinal absorption of acyl-tetragastrin derivertives in rats. Pharm. Res., 10:1488-1492 (1993).
Masahiro Murakami, Yoko Kusanoi, Kanji Takada, and Shozo Muranishi, Assessment of enhancing ability of medium-chain alkyl saccharides as new absorption enhancers in rat rectum. Int. J. Pharm., 19: 159-169 (1992).
Masahiro Murakami, Kanji Takada and Shozo Muranishi, Further mechanistc study on intestinal absorption enhanced by unsaturated fatty acids: reversible effect by sulfhydryl modification. Biochim. Biophys. Acta, 1117, 83-89 (1992).
Shozo Muranishi, Masahiro Murakami, Minoru Hashizume, Keigo Yamada, Shigeru Tashima and Yoshiaki Kiso, Trials of lipid modification of peptide hormones for intestinal delivery. J. Controlled Release, 19: 178-188 (1992).
Minoru Hashizume, Takayuki Douen, Masahiro Murakami, Akira Yamamoto, Kanji Takada and Shozo Muranishi, Improvement of large intestinal absorption of insulin by chemical modification with palmitic acid. J. Pharm. Pharmacol., 44: 555-559 (1992).
Keigo Yamada, Masahiro Murakami, Akira Yamamoto, Kanji Takada and Shozo Muranishi, Improvement of intestinal absorption of thyrotropin-releasing hormone by chemical modification with lauric acid. J. Pharm. Pharmacol., 44: 717-721 (1992).
Shozo Muranishi, Atsushi Sakai, Keigo Yamada, Masahiro Murakami, Kanji Takada, and Yoshiaki Kiso, Lipophilic peptides: synthesis of lauroyl thyrotropin-releasing hormone and its biological activity. Pharm. Res., 8:649-652 (1991).
Toshihide Ohtani, Masahiro Murakami, Akira Yamamoto, Kanji Takada, and Shozo Muranishi, Effect of absorption enhancers on pulmonary absorption of fluorescein isothiocyanate dextrans with various molecular weights, Int. J. Pharm., 77:141-150 (1991).
Masahiro Murakami, Kanji Takada, Tatsuzo Fujii, and Shozo Muranishi, Intestinal absorption enhanced by unsaturated fatty acids: inhibitory effect of sulfhydryl modifiers. Biochim. Biophys. Acta, 939:238-246 (1988).
Hiroshi Fukui, Masahiro Murakami, Hiroshi Yoshikawa, Kanji Takada, and Shozo Muranishi, Studies on promoting effect of lipid-surfactant mixed micelles (MM) on intestinal absorption of colloidal particles. Dependence on particle size and administration site. J Pharmacobio-Dyn., 10:236-242 (1987).
Masahiro Murakami, Hiroshi Yoshikawa, Kanji Takada, and Shozo Muranishi, Effect of oleic acid vesicles on intestinal absorption of carboxyfluorescein in rats. Pharm. Res., 3:35-40 (1986).
Masahiro Murakami, Kanji Takada, and Shozo Muranishi, Promoting effect of Azone on intestinal absorption of poorly absorbable drugs in rats. Int. J. Pharm., 31:231-238 (1986).
Hiroshi Fukui, Masahiro Murakami, Kanji Takada, and Shozo Muranishi, Combinative promotion effect of Azone and Fusogenic fatty acid on the large intestinal absorption in rat. Int. J. Pharm., 31:239-246 (1986).
Noriko Hashida, Masahiro Murakami, Hiroshi Yoshikawa, Kanji Takada, and Shozo Muranishi, Intestinal absorption of carboxyfluorescein entrapped in liposomes in comparison with its administration with lipid-surfactant mixed micelles. J. Pharmacobio-Dyn., 7: 195-203 (1984).

大阪大谷大学 薬学部 薬剤学講座

Osaka Ohtani University

Department of Pharmaceutics, Faculty of Pharmacy

OYANAGUI Y, TANIGUCHI M, IWATA M, MURAKAMI M, Inhibition of immunoglobulin G-catalyzed hydrogen peroxide generation by dexamethasone and piroxicam. Life Sci, Vol.73, No.10, 1333-1346 (2003)

OYANAGUI Y, TANIGUCHI M, IWATA M, MURAKAMI M, Inhibition of immunoglobulin G-catalyzed hydrogen peroxide generation by dexamethasone and piroxicam. Life Sci, Vol.73, No.10, 1333-1346 (2003)

KOGA K, KAWASHIMA S, SHIBATA N, TAKADA K, MURAKAMI M, Preparation and Rectal Absorption of Highly Concentrated Glycyrrhizin Solution. Biol Pharm Bull, Vol.26, No.9, 1299-1305 (2003)

EIAMTRAKARN S, ITOH Y, KISHIMOTO J, YOSHIKAWA Y, SHIBATA N, MURAKAMI M, TAKADA K, Gastrointestinal mucoadhesive patch system (GI-MAPS) for oral administration of G-CSF, a model protein. , Biomaterials, Vol.23, No.1, 145-152 (2002)

SHIBATA N, OHNO T, SHIMOKAWA T, HU Z, YOSHIKAWA Y, MURAKAMI M, TAKADA K, KOGA K, Application of pressure-controlled colon delivery capsule to oral administration of glycyrrhizin in dogs. J Pharm Pharmacol, Vol.53, No.4, 441-447 (2001)

UCHIYAMA T, KOTANI A, TATSUMI H, KISHIDA T, OKAMOTO A, OKADA N, MURAKAMI M, FUJITA T, YAMAMOTO A , Development of Novel Lipophilic Derivatives of DADLE (Leucine Enkephalin Analogue): Intestinal Permeability Characteristics of DADLE Derivatives in Rats. Pharm Res, Vol.17, No.12, 1461-1467 (2000)

SHIBATA N, SHIMOKAWA T, JIANG Z-Q, JEONG Y-I, OHNO T, KIMURA G, YOSHIKAWA Y, TAKADA K, KOGA K, Characteristics of Intestinal Absorption and Disposition of Glycyrrhizin in Mice. Biopharm Drug Dispos, Vol.21, No.3, 95-101 (2000)

KOGA K, KAWASHIMA S, OHMACHI K, MURAKAMI M, TAKADA O, Determination of 18α-glycyrrhizin and 18β-glycyrrhizin in dog plasma by high-performance liquid. chromatography. J Chromatogr B, Vol.738, No.1, 165-168 (2000)

KOGA K, OHYASHIKI T, KAWASHIMA S, MURAKAMI M, Modification of ceftibuten transport by the addition of non-ionic surfactants. Eur J Pharm Biopharm, Vol.49, No.1, 17-25 (2000)

YOSHIKAWA Y, HU Z, KIMURA G, MURAKAMI M, TAKADA K, YOSHIKAWA H, A Dissolution Test for a Pressure-controlled Colon Delivery Capsule: Rotating Beads Method. J Pharm Pharmacol, Vol.51, No.9, 979-989 (1999)

KOGA K, KAWASHIMA S, MURAKAMI M, Effects of Fatty Acid Glycerol Esters on Intestinal Absorptive and Secretory Transport of Ceftibuten. Biol Pharm Bull, Vol.22, No.4, 402-406 (1999)

KOGA K, KAWASHIMA S, MURAKAMI M, Modification of Ceftibuten Transport by Changes in Lipid Fluidity Caused by Fatty Acid Glycerol Esters. Biol Pharm Bull, Vol.22, No.1, 103-106 (1999)

SASAKI I, TOZAKI H, MATSUMOTO K, ITO Y, FUJITA T, MURAKAMI M, MURANISHI S, YAMAMOTO A, Development of an Oral Formulation of Azetirelin, a New Thyrotropin-Releasing Hormone (TRH) Analogue, Using n-Lauryl-β-D-maltopyranoside as an Absorption Enhacer. Biol Pharm Bull, Vol.22, No.6, 611-615 (1999)

Tozaki H, Odoriba T, Iseki T, Taniguchi T, Fujita T, Murakami M, Muranishi S, Yamamoto A., Use of protease inhibitors to improve calcitonin absorption from the small and large intestine in rats. J Pharm Pharmacol. 50(8), 913-920 (1998)

Ying-shu Quan, Koji Hattori, Ewa Lundborg, Takuya Fujita, Masahiro Murakami, Shozo Muranishi, Akira Yamamoto, Effectiveness and toxicity screening of various absortion enhancers using Caco-2 cell monolayers, Biol. Phar. Bull., 21(6):615-620 (1998).

Kenjiro Koga, Masahiro Murakami, Susumu Kawashima, Effects of fatty acid sucrose esters on ceftibuten transport by rat intestinal brush-border membrane vesicles. Biol. Pharm. Bull., 21(7): 747­751 (1998).

Shozo Muranishi, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Potential for lymphatic targeting of peptides. J. Control. Release, 46:157-164 (1997).

Isao Sasaki, Takashi Tamura, Tomoko Shibakawa, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, and Shozo Muranishi, Metabolism of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, by intestinal microorganisms. Pharm. Res., 14: 1004-1007 (1997).

Kenjiro Koga, Masahiro Murakami, Susumu Kawashima, Contribution of fluidity to the uptake of disopyramide by rat intestinal brush-border membrane vesicles. Biol. Pharm. Bull. 20:674-679 (1997).

Koichiro Tanaka, Takuya Fujita, Toshihiko Yamamoto, Masahiro Murakami, Akira Yamamoto, and Shozo Muramishi, Enhancement of intestinal transport of thyrotropin-releasing hormone via a carrier-mediated system by chemical modification with lauric acid, Biochim. Biophys. Acta, 1283:119-126(1996)

Shozo Muranishi, Takuya Fujita, Masahiro Murakami, and Akira Yamamoto, Lymphatic transfer of macromolecules after intrapulmonary administration in the presence or absence of various absorption enhancers in rats. The Pharmazie, 51:331-336 (1996).

Kazunari Setoh, Masahiro Murakami, Naoko Araki, Fujita Takuya, Akira Yamamoto, and Shozo Muranishi, Improvement of transdermal delivery of tetragastrin by lipophilic modification with fatty acids. J. Pharm. Pharmacol., 47:808-811 (1995).

Isao Sasaki, Kouichiro Tanaka, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi, Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue II: Biol. Pharm. Bull., 18:891-894 (1995).

Takashi Tamura, Takuya Fujita, Yukiko Itoh, Satomi Sugimoto, Hidenori Yamada, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi, Synergistic anti-tumor effects of mitomycin C and bile salts against L12to cells. Biol. Pharm. Bull., 18:1109-1113 (1995).

Hiroyuki Asada, Takayuki Douen, Yoshiko Mizokoshi, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi, Stability of acyl derivatives of insulin in the small intestine: relative importance of insulin association characteristics in aqueous solution. Pharm. Res., 11:1115-1120 (1994).

Hiroyuki Asada, Takayuki Douen, Yoshiko Mizokoshi, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi, Stability of acyl derivatives of insulin in the small intestine: relative importance of insulin association characteristics in aqueous solution. Pharm. Res., 11:1115-1120 (1994).

Hiroyuki Asada, Takayuki Douen, Yoshiko Mizokoshi, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi, Stability of acyl derivatives of insulin in the small intestine: relative importance of insulin association characteristics in aqueous solution. Pharm. Res., 11:1115-1120 (1994).

Toshio Taniguchi, Kaori Rikyu, Tomoko Tsuji, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi, Regional differences in the efffects of various protease inhibitors on the intestinal absorption and stability of insulin and calcitonin in rats. Pharm. Res., 11:1496-1500 (1994).

Isao Sasaki, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Eiji Nakamura, H. Imasaki, Shozo Muranishi, Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue I: possible factors for the low bioavailability in rats. Biol. Pharm. Bull., 16:1256-1261 (1994).

Taishi Okagawa, Takuya Fujita, Masahiro Murakami, Akira Yamamoto and Shozo Muranishi, Susceptibility of ebilatide to proteolysis in rat intestinal fluid and homogenates and its protection by various protease inhibitors. Life Science, 55:677-683 (1994).

Akira Yamamoto, Toshio Taniguchi, Kaori Rikyuu, Tomoko Tusji, Takuya Fujita, Masahiro Murakami and Shozo Muranishi, Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. Pharm. Res., 10 (11): 1496-1500 (1994).

Masahiro Murakami, Yoko Kusanoi, Kanji Takada, and Shozo Muranishi, Assessment of enhancing ability of medium-chain alkyl saccharides as new absorption enhancers in rat rectum. Int. J. Pharm., 19: 159-169 (1992).

Masahiro Murakami, Kanji Takada and Shozo Muranishi, Further mechanistc study on intestinal absorption enhanced by unsaturated fatty acids: reversible effect by sulfhydryl modification. Biochim. Biophys. Acta, 1117, 83-89 (1992).

Shozo Muranishi, Masahiro Murakami, Minoru Hashizume, Keigo Yamada, Shigeru Tashima and Yoshiaki Kiso, Trials of lipid modification of peptide hormones for intestinal delivery. J. Controlled Release, 19: 178-188 (1992).

Minoru Hashizume, Takayuki Douen, Masahiro Murakami, Akira Yamamoto, Kanji Takada and Shozo Muranishi, Improvement of large intestinal absorption of insulin by chemical modification with palmitic acid. J. Pharm. Pharmacol., 44: 555-559 (1992).

Keigo Yamada, Masahiro Murakami, Akira Yamamoto, Kanji Takada and Shozo Muranishi, Improvement of intestinal absorption of thyrotropin-releasing hormone by chemical modification with lauric acid. J. Pharm. Pharmacol., 44: 717-721 (1992).

Shozo Muranishi, Atsushi Sakai, Keigo Yamada, Masahiro Murakami, Kanji Takada, and Yoshiaki Kiso, Lipophilic peptides: synthesis of lauroyl thyrotropin-releasing hormone and its biological activity. Pharm. Res., 8:649-652 (1991).

Toshihide Ohtani, Masahiro Murakami, Akira Yamamoto, Kanji Takada, and Shozo Muranishi, Effect of absorption enhancers on pulmonary absorption of fluorescein isothiocyanate dextrans with various molecular weights, Int. J. Pharm., 77:141-150 (1991).

Masahiro Murakami, Kanji Takada, Tatsuzo Fujii, and Shozo Muranishi, Intestinal absorption enhanced by unsaturated fatty acids: inhibitory effect of sulfhydryl modifiers. Biochim. Biophys. Acta, 939:238-246 (1988).

Hiroshi Fukui, Masahiro Murakami, Hiroshi Yoshikawa, Kanji Takada, and Shozo Muranishi, Studies on promoting effect of lipid-surfactant mixed micelles (MM) on intestinal absorption of colloidal particles. Dependence on particle size and administration site. J Pharmacobio-Dyn., 10:236-242 (1987).

Masahiro Murakami, Hiroshi Yoshikawa, Kanji Takada, and Shozo Muranishi, Effect of oleic acid vesicles on intestinal absorption of carboxyfluorescein in rats. Pharm. Res., 3:35-40 (1986).

Masahiro Murakami, Kanji Takada, and Shozo Muranishi, Promoting effect of Azone on intestinal absorption of poorly absorbable drugs in rats. Int. J. Pharm., 31:231-238 (1986).

Hiroshi Fukui, Masahiro Murakami, Kanji Takada, and Shozo Muranishi, Combinative promotion effect of Azone and Fusogenic fatty acid on the large intestinal absorption in rat. Int. J. Pharm., 31:239-246 (1986).

Noriko Hashida, Masahiro Murakami, Hiroshi Yoshikawa, Kanji Takada, and Shozo Muranishi, Intestinal absorption of carboxyfluorescein entrapped in liposomes in comparison with its administration with lipid-surfactant mixed micelles. J. Pharmacobio-Dyn., 7: 195-203 (1984).

大阪大谷大学　薬学部　薬剤学講座

Kenjiro Koga, Masahiro Murakami, Susumu Kawashima, Effects of fatty acid sucrose esters on ceftibuten transport by rat intestinal brush-border membrane vesicles. Biol. Pharm. Bull., 21(7): 747751 (1998).